Glioblastomas are the most common human brain tumors. These brain tumors are more common in men than women. A recent study published in ‘The Journal of Clinical Investigation’ found out why glioblastomas are more prevalent in men.
Researchers from the Washington University in St. Louis, MO, found that retinoblastoma protein (RB) is more active in the brain of women than in men and this protein is associated with the reduced risk of cancer.
In this study, Dr. Joshua Rubin with the team of researchers made a cell model of glioblastoma and conduct numbers of experiments to see its growth factors. The study confirmed that in male brain cells, growth of this tumor is faster than in female brain cells.
The results of the study showed that disabling RB protein in the brain cells of females also make female brain cells susceptible to cancer.
Dr. Joshua Rubin said, “In clinical trials, we typically examine data from male and female patients together, and that could be masking positive or negative responses that are limited to one sex”. He added, “At the very least, we should think about analyzing data for males and females separately in clinical trials.”